A brutal scourge stalks the land. Yoma, monsters driven by a hunger satisfied by only one quarry: Humanity. The dark breed knows but a singular foe: Claymore. Human-Yoma hybrids of extraordinary strength and cunning, the Claymores roam from skirmish to skirmish delivering salvation by the edge of a blade... for a fee.

A brutal scourge stalks the land. Yoma, monsters driven by a hunger satisfied by only one quarry: Humanity. The dark breed knows but a singular foe: Claymore. Human-Yoma hybrids of extraordinary strength and cunning, the Claymores roam from skirmish to skirmish delivering salvation by the edge of a blade... for a fee.

The twisting tale of Clare continues. A disturbing glance into the past reveals the forces which molded an orphan into a warrior, where monsters come in all shapes and heroes sometimes hide their greatest glories. Lore tells of twin goddesses, worshipped for their boundless grace - two angels of light called Teresa and Clare.

A Claymore – a female warrior named for the sword she carries – travels from medieval village to village to destroy Yoma, monsters who disguise themselves as humans and who are almost impossible to kill. Claymores are half-humans, half-demons who willingly transformed themselves by mixing their blood with monster's blood.

Clare and a group of Claymores are sent to the north to battle a group of Yoma that have banded together under the command of Isley, a powerful Awakened Being. When the warriors arrive, they find their new enemies to be unusually dangerous. They are incredibly strong, well-organized, and seem to have a plan to dominate the entire region. Will the Claymores be able to stop this monstrous army?

In the northern town of Pieta, Clare and a force of Claymores battle a troupe of Awakened Ones to prevent them from advancing south. Their orders are to hold off the evil horde at all costs, while the Organization prepares a secret weapon. Clare and her comrades realize that theirs is a suicide mission. As their friends fall one by one, the warriors band together to make their last stand.

Seven years have passed since the devastating battle in Pieta, and now a new generation of Claymores carries on the fight against the Awakened Ones. However, the mystery of Claire's fate, and that of her comrades, resurfaces after a surprising discovery made by a young Claymore.

Audrey and Rachel continue their battle against Riful of the West, and Clare learns some surprising truths about Priscilla, Isley and the struggle for power amongst the Three Great Awakened Ones. Meanwhile, the Organization decides to send Miata and Clarice out on an important mission, but will Clarice be able to keep her unstable young charge in line?

Claire and the orphan Raki travel to the town of Rabona, where a Yoma has been stalking the priests inside the cathedral. The creature could be one of the guards, or even a priest, but this time Claire won't be able to sense its aura. Does she stand a chance against the stealthy Yoma?

Clare's first battle with the Yoma of Rabona cathedral has left her body drained and shattered. With no time to recover, she must face the creature again after it chooses Raki as its next victim. Luckily, Raki remembers that he is carrying Clare's trusted broadsword and manages to get it into her hands. But unlike Clare, the Yoma is fighting at full strength and thirsting for blood...

Teresa, a powerful Claymore, saves a young girl from her bandit captors and leaves the child in the care of some villagers. But triumph quickly gives way to despair when the situation takes a tragic turn, and Teresa is forced to kill a human - an act that will condemn her to death at the hands of her own kind.