Beings who possess animal-like powers walk among humans in this alternate universe. These mysterious mutants, the +Anima, are shunned by society. Four outcasts in particular - Cooro, a boy with crow-like powers; Husky, a fish-boy; Senri, a bear +Anima; and a girl named Nana, who wields the power of the bat - search for others like themselves while trying to gain acceptance in a world cruel to anyone or anything that is different.

Cooro and the others discover the first Yellow Valley Race, a race exclusively for +Anima. Cooro and Senri decide to enter, and while waiting for the race to start, they run into Lyra, a girl whom Cooro knew when he was younger. But when Cooro knew her, she wasn't a +Anima... How can she be one now - and is that the only secret she holds?

Cooro and his +ANIMA friends find themselves in the beehive forest. Cooro ends up doing a favor for people in a nearby town. His +ANIMA powers must help him stop a stinging foe! The +ANIMA band's troubles never cease as their adventure continues.

In a new town, Cooro befriends Shadow, a young man who dreams of flying to help provide for his family. Igneous and his army show up again and create new problems for the +ANIMA. Could Cooro and his companions have finally found a place where they will be accepted or will they remain wanderers and outcasts forever?

While on their journey, Cooro and the others pass through large and lively Maggie Vil. The soft-spoken town leader Maggie convinces Cooro and company to go watch the world-famous coliseum games. Senri and Husky join the games after getting caught up in all the action. But it seems too much action could be a bad thing - will Cooro and the others find their way out of the coliseum?

Husky, Senri, Nana and Cooro happen upon an apple orchard owned by a lonely woman named Emma, who invites them all to stay with her. But while the others feel her offer to be a little unsettling and would rather leave, Cooro couldn't be happier to have finally found a mother. Cooro's long journey of acceptance may finally be over... but are the others prepared to leave him behind?

The party, led by Igneous, come across a bear in the mountains just as something goes wrong with Senri and he collapses. The Kim-un-kur let Igneous and his troops into their camp because they are concerned about Senri... but their chief, Mukar, tells them that he has no intention of changing their relations with Astaria.

Cooro and his companions travel through a dark tunnel on the way to Sailand. While Nana contemplates telling Husky the truth, he gets separated from the group! When Husky goes to find him, he also gets lost. Will the two of them be able to find Cooro again? And what fate awaits them in Sailand, where +Anima are kept as slaves?

Cooro and his group arrive at Stella, where they learn that Husky has already been sold to a low-ranking noble. Ed tells Cooro and Nana to come up with a plan to free Husky on their own. Meanwhile, Husky, who had disguised himself as a mermaid, has his own plan to sneak into the palace through the Stella waterways, but his plans are thwarted when Cooro and Nana come and kidnap him.

Cooro and the others find themselves in a town that has just been graced with the presence of an angel. Cooro realizes right away that the angel is a +Anima. But the "angel" doesn't like being discovered and turns the town against Cooro telling them he's a messenger of death. When researchers arrive to take the angel away, will Cooro and friends be able to save him?

AI buster follows the adventures of Albireo as he plays a beta version of what will soon be known as "The World." In his journeys, Albireo encounters Lycoris, a failed version of Aura and makes a connection that may turn out to be unbreakable.

Alcor focuses on a Twin Blade named Nanase who falls in love with Silabus. Wanting to spend more time with him, Nanase joins Canard, but joy quickly turns to jealousy when she witnesses just how much Silabus is beholden to Alkaid, who has just become the new Emperor of the Demon Palace Arena. Thus begins Nanase's quest to better Alkaid in the hopes that Silabus will finally notice her...