A virus incubating in young Daisy Ogami's blood may hold the key to saving the world... or destroying it. The Cygnat Owari corporation wants her secret - no matter what it may be, and no matter what the cost in money or lives. Daisy's only protector is Itto - an android bodyguard falsely accused of killing her father.

For over a year, Itto and Daisy have managed to stay one jump ahead of the assassins on their trail. But now the agents of Cygnat Owari have captured Itto, hoping to extract from him through torture Daisy's hiding place. Only Itto's captors have not reckoned with the fallout of their own actions: an operative whom they fired has located Daisy, and is setting the stage for Itto to take his revenge on his former employers...

A ground-up re-imagining of the original Lone Wolf and Cub manga, this series is being done in association with, and under the watchful eye of, Kazuo Koike, the writer and co-creator of Lone Wolf and Cub.