Ippo Makunouchi's first title defense match is set. The challenger's name is Kazuki Sanada. The strong opponent is currently also a medical school student. Using his knowledge of human biology, he has a thorough understanding of which part of his opponent's body to hit in order to defeat him by accurately delivering the most damage and to drain the opponent's stamina. Ippo faces with a boxer who possesses the most intellectual fighting skills in Japan.

Furthermore, Kazuki Sanada's trainer surprisingly is Chief Kamogawa's rival during his prime, Dankichi Hama, who is now giving instructions on his legendary fight technique, the "Flying Swallow" to Sanada. Ippo vs. Sanada and the collision of the coaches, Chief Kamogawa vs. Dankichi Hama - each of these individuals' thoughts entangle as the day of the battle finally arrives! Will Ippo be able to find his way through the deadly Flying Swallow and claim victory?

Spoken Languages: English, Japanese, English subtitles.