Welcome to Neo-Tokyo, built on the ashes of a Tokyo annihilated by a blast of unknown origin that triggered World War III. The lives of two streetwise teenage friends, Tetsuo and Kaneda, change forever when paranormal abilities begin to waken in Tetsuo, making him a target for a shadowy agency that will stop at nothing to prevent another catastrophe like the one that leveled Tokyo. At the core of the agency's motivation is a raw, all-consuming fear of an unthinkable, monstrous power known only as Akira.

The line between man and machine has been inexorably blurred as humans rely on the enhancement of mechanical implants and robots are upgraded with human tissue. In this rapidly converging landscape, cyborg superagent Major Motoko Kusanagi is charged to track down the craftiest and most dangerous terrorists and cybercriminals, including "ghost hackers" who are capable of exploiting the human/machine interface and reprogramming humans to become puppets to carry out the hackers' criminal ends.