A brutal scourge stalks the land. Yoma, monsters driven by a hunger satisfied by only one quarry: Humanity. The dark breed knows but a singular foe: Claymore. Human-Yoma hybrids of extraordinary strength and cunning, the Claymores roam from skirmish to skirmish delivering salvation by the edge of a blade... for a fee.

The twisting tale of Clare continues. A disturbing glance into the past reveals the forces which molded an orphan into a warrior, where monsters come in all shapes and heroes sometimes hide their greatest glories. Lore tells of twin goddesses, worshipped for their boundless grace - two angels of light called Teresa and Clare.

Whispers of conspiracy fill the air, but the gravest peril is not hidden. Enter Ophelia, a Claymore of joyful cruelty with a zealot's devotion to the massacre of all who have Awakened. And Clare will suffer as her prey. Flesh will fall from bone, but there will be no rest until Teresa is avenged.

A brutal scourge stalks the land. Yoma, monsters driven by a hunger satisfied by only one quarry: Humanity. The dark breed knows but a singular foe: Claymore. Human-Yoma hybrids of extraordinary strength and cunning, the Claymores roam from skirmish to skirmish delivering salvation by the edge of a blade.

A Claymore – a female warrior named for the sword she carries – travels from medieval village to village to destroy Yoma, monsters who disguise themselves as humans and who are almost impossible to kill. Claymores are half-humans, half-demons who willingly transformed themselves by mixing their blood with monster's blood.

Clare and a group of Claymores are sent to the north to battle a group of Yoma that have banded together under the command of Isley, a powerful Awakened Being. When the warriors arrive, they find their new enemies to be unusually dangerous. They are incredibly strong, well-organized, and seem to have a plan to dominate the entire region. Will the Claymores be able to stop this monstrous army?

In the northern town of Pieta, Clare and a force of Claymores battle a troupe of Awakened Ones to prevent them from advancing south. Their orders are to hold off the evil horde at all costs, while the Organization prepares a secret weapon. Clare and her comrades realize that theirs is a suicide mission. As their friends fall one by one, the warriors band together to make their last stand.

Seven years have passed since the devastating battle in Pieta, and now a new generation of Claymores carries on the fight against the Awakened Ones. However, the mystery of Claire's fate, and that of her comrades, resurfaces after a surprising discovery made by a young Claymore.

Audrey and Rachel continue their battle against Riful of the West, and Clare learns some surprising truths about Priscilla, Isley and the struggle for power amongst the Three Great Awakened Ones. Meanwhile, the Organization decides to send Miata and Clarice out on an important mission, but will Clarice be able to keep her unstable young charge in line?