Sumire is your average everyday schoolgirl. That is, if your average everyday schoolgirl can not only sense ghosts and demons, but can also dispose of them accordingly. So when she finally meets Lucia, a specter-fighting, eyepatch-wearing power-girl from the Venus Vanguard, it's a match made in heaven. Or rather - Hell, as it were. Together, these two will work to rid the world of the dark forces called Virus that lurk amongst us.

As the battle for human souls rages on, newer and more powerful Virus demons arise to confront mankind's last line of defense, the Venus Vanguard. To make matters worse, one of the newest Virus seems completely immune to the Vanguard's weaponry, and it's taken a personal interest in destroying Sumire!

While the pressure of eliminating viruses seems to have abated somewhat, there are still resident evils that lurk beneath the surface. Sumire's blossoming relationship with Yoshiki has a dark side, and Nahashi and Laura are intensifying their search for Lucif. Their goal: to ultimately put an end to the scourge that is threatening their existence.

After a lifetime of seeing ghosts, young Sumire is recruited by powerful Lucia to fight demons! The girls battle darkness as members of the Venus Vanguard, a group dedicated to ridding the world of its greatest threat: Virus. But as they discover why every life is worth saving, they also learn that they carry their own unlocked potential for evil. The Virus rages out of control, but Sumire and Lucia are prepared to give it the beating it truly deserves.

Sumire Takahana is a seemingly normal school girl cursed with the ability to see malevolent ghosts known as "Viruses." Her life hits a crossroads after a run-in with a gothic lolita-clad monster killer for hire, Lucia Nahashia. Not content to stay on the sidelines while Viruses prey on the weak, Sumire decides to join forces with the mysterious eyepatch-wearing Lucia to hunt down Viruses before they can hurt anyone else.

Sumire Takahana is a seemingly normal school girl cursed with the ability to see malevolent ghosts known as "Viruses." Her life hits a crossroads after a run-in with Lucia, a "gothic lolita" clad monster killer for hire. Not content to stay on the sidelines while these Viruses prey on the weak, Sumire decides to join forces with the mysterious eyepatch-wearing Lucia to hunt down the Viruses before they can hurt anyone else.

As Venus Vangard squares off against Sonoka's evil minions, Sumire's berserker powers spiral out of control... and it's Lucia who's caught in the middle!

As mistrust and unease form within Sonoka's ranks, the evil mistress decides to grant her minions Guy and Ruka just what they desire most: the power to obliterate Lucia and Sumire once and for all! Is this the ultimate showdown or a sign of much darker things to come?

While Sonoka-sama's minions continue their attacks on those with the "vision" like Sumire, pieces of the puzzle start to fall into place as Lucia and her friends discover the contents of her dead mother's forgotten diary!

It's been one battle after another against stronger and stranger foes. Now, the ultimate showdown between the crew of Venus Vanguard and their mysterious enemy has come. Will Sumire's feelings for her boyfriend Yoshiki survive the terrible discovery she's about to make?

When Sumire Takahana joined Venus Vanguard to hunt monsters known as "Viruses," she never knew it would come to this. The ultimate battle between the crew of Venus Vanguard and their deadly Enemy is now at full tilt. The lives of Sumire and Lucia hang in the balance, not to mention the very fate of the world.

Sumire Takahana is a seemingly normal school girl cursed with the ability to see malevolent ghosts known as "Viruses." Her life hits a crossroads after a run-in with a gothic lolita-clad monster killer for hire, Lucia Nahashia. Not content to stay on the sidelines while Viruses prey on the weak, Sumire decides to join forces with the mysterious eyepatch-wearing Lucia to hunt down Viruses before they can hurt anyone else. This omnibus collects volumes 1-3 of Venus Versus Virus.