More than 100 years have past since the battle between Jonathan Joestar and the vampire, Dio Brando. Now Dio's escape from the ocean depths awakens the psychic power known as "Stand" within 17-year-old Jotaro "JoJo" Kujo and his grandfather Josef Joestar. Now they must battle the immortal vampire Dio, who holds Jotaro's mother Holley prisoner in a nightmare-filled coma.

More than 100 years have past since the battle between Jonathan Joestar and the vampire, Dio Brando. Now Dio's escape from the ocean depths awakens the psychic power known as "Stand" within 17-year-old Jotaro "JoJo" Kujo and his grandfather Josef Joestar. Now they must battle the immortal vampire Dio, who holds Jotaro's mother Holley prisoner in a nightmare-filled coma.

There is still no clue as how to defeat the Hanged Man, who reveals himself only through mirror reflections. How can they find a way to defeat this enigmatic Stand...?

While seeking solace in the nearest city, hordes of zombies descend upon Jotaro and his comrades, while "Justice" towers over them in the dark skies!

Voyaging through the Middle East, Jotaro and his companions finally reach Egypt. There, they are met by a helicopter sent by the Speed Wagon Foundation to deliver a new addition to their group--the mysterious Iggi "The Fool." When the helicopter crashes a short time later under bizarre circumstances, the group investigates, only to find themselves pitted against another of Dio's assassins - N'Dool and his deadly Stand, "God Geb."

Seeking information on Dio's whereabouts, the companions encounter a gambler named D'Arby who claims to have the information they need. The catch is, they have to beat him in the ultimate wager - one where their very souls are at stake! Can the Joestar party outwit a master gambler at his own game?

Dio pursues Joseph through the streets of Cairo, leaving an incredible swath of death and destruction in his wake. Another of the companions comes to Joseph's aid, only to be crushed by the power of Dio's Stand, "The World." As the shattered hero lies alone and dying, he realizes in the last moments of life the true nature of Dio's Stand... but can he warn the others before it's too late?